EXPERIMENTAL MALARIA IN MAN. I. PHYSICAL DETERIORATION AND RECOVERY 1

Experimental Malaria in Man

It is generally known that malaria may produce signs of impaired liver function. In studies on experimentally induced malaria in this laboratory (1, 2), special efforts were made in an attempt to obtain information on four aspects of the question as to the effects on the liver: (1) The magnitude and character of the impairment as indicated by the several methods customarily used in the study of...

Man, monkeys and malaria.

Bizarre though it may now seem, in the last century a whole series of experiments was conducted that involved injecting fresh monkey blood into human volunteers or patients. The reasons, valid at the time, were either to treat neurosyphilis with a relatively benign simian malaria infection (so-called pyrogen therapy), or to establish which monkey malaria species were potential zoonotic reservoi...

I.1. Physical motivation.

Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria

CD4 T cell-dependent antibody responses are essential for limiting Plasmodium parasite replication and the severity of malaria; however, the factors that regulate humoral immunity during highly inflammatory, Th1-biased systemic infections are poorly understood. Using genetic and biochemical approaches, we show that Plasmodium infection-induced type I interferons limit T follicular helper accumu...

hydrochlorothiazide detection in urine samples by hplc-dad and experimental design dispersive l-l microextraction

hydrochlorothiazide (hct) is a diuretic agent which is shown to be effective in the treatment of hypertension. literature reports have demonstrated that urinary excretion data may be used to assess the bioavailability of various formulations containing this thiazide. also hct consumption by the athletes is one of the drugs which should be regulated by world anti-doping agency (wada), because of...